The Last Enemy - Parts 1,2 & 3 - 1934-2054 Page 2

  Chapter 2

  “On the train you found a copy of Paris Match, the most popular magazine at the time, where L’Oreal had posted research and development jobs available for their soon-to-be-launched skin products division.”

  “Yes. At first glance, however, I ignored it. I was far too advanced for the positions they were offering and the only thing my research and the job had in common was that there were cells involved. But by the time the train entered the Gare du Nord in Paris, I had come to the conclusion that it was the perfect opportunity and I sent my resume directly from the post office that was inside the station.

  A few days later I received a telegram at my father’s house that invited me for an interview at their headquarters in Clichy, located in the outskirts of Paris. It was there where I met Xavier Langlois, the director of the hair products department, at that time.

  He was a very tall man, dressed in an impeccable suit. He showed me into his spacious office, furnished with antique chairs and a huge round table that served as his desk. He greeted me by asking why a brilliant scientist like myself would ever consider joining a cosmetics company and added that he would not hire me in any case, as I must have some kind of mental problem.

  Tough start. One hundred and twenty-two years have passed and I still vividly remember every moment of that interview. He had been brutally honest. After having said that, he leaned back into his chair and stared at me, waiting for my explanation. It was time to make my move.

  “Monsieur,” I replied, “I read in the job posting that you are looking for a qualified biochemist to run an ambitious project in cosmetic research. After reading my resume, you cannot question my expertise. On the contrary, you have not yet demonstrated to me that your project is ambitious enough for me to consider it.”

  Xavier’s face transformed. He cleared his throat, as an attempt to compensate for his rude introduction and spoke simply.

  “Indeed, this project is too intricate to describe in an ad. As you well know, we produce top-selling products, and we want to set up a lab to better investigate the function of cells and apply this knowledge to create rennovated products.

  Your education as a physician and your recent experience in cell research obviously qualifies you for the job, but I doubt that you would appreciate our environment. I hope to bring new ground-breaking products to the market.”

  ”Monsieur, then I think we share the same ideas. One of the main problems I am having now at the university, is that we are not focused enough on improving the common good of society.

  We have studied the code that rules cell replication, but do not want to seriously commit our efforts to how, for example, this could be applied to aging. Therefore I think that I would be able to contribute more at L’Oreal than at Cavendish Lab in Cambridge.

  That is why I am here.”

  Xavier expression, attentive up until now, opened into a broad smile.

  “Are you telling me that you plan to use L’Oreal labs and resources to turn them into a sorcerer’s cave to try to produce the eternal life potion?”

  “Well, that would definitely be the main goal. Unfortunately, I have to be realistic and admit that most likely I will only end up designing lots of tremendously successful skin cosmetics that will provide L’Oreal with stacks of money and a decent career for myself.”

  Xavier burst into laughter and ringed the bell on his desk to call in his assistant. A few seconds later, a young woman opened the door and before she could even step in the office, Mr. Langlois told her to prepare the paperwork. I was expected to start working the next day.

  “Louis, in retrospect, do you think Mr. Langlois believed your true goals?”

  “Not for the first few years. He kept up with my work and he clearly saw that I was also doing a lot of studies and experiments not directly correlated to product research. On the other side, he was also seeing that this side research sometimes contributed to the main product development, almost always with excellent results. So I believe he just figured that that was just my way of working.

  He would give me the objectives and ask me how much I needed to achieve them, without further questioning. By 1965, I had already developed a drug able to improve the replication efficiency of a set of skin and hair cells, and this was channeled into extremely popular products. My career took off and by 1968, Xavier was seriously thinking about handing me the responsibility of the whole product development of L’Oreal. I balked at the idea. I needed to focus on research, not to be a company executive.

  He was puzzled at my response, so in the early weeks of the summer of 1968, he called me into his office and asked me why I was refusing a promotion. Was I under the influence of all those communists that were rocking the streets of Paris and of half of Europe?

  I stuck to the truth and updated him on everything I was finding in my free time, among which, the discovery of telomeres in skin cells.

  Telomeres are the structures that allow DNA to replicate and form an exact copy of the original cell, except over time they get shorter, until the cell is no longer able to replicate correctly and eventually dies. I had sent some previous results to my old classmates at Cambridge for some additional review and I could simply not leave the job half done.

  Xavier stood up from his desk, and stared at me with a frown. Turns out that I had indeed created my own sorcerer’s cave in search of the eternal life potion. Just like in my first interview, I used the interest of the company to defend my point.

  I was just a few months away from a major breakthrough in the study of the cell aging process and he would risk spoiling this over a promotion? He eventually gave in, and I could keep running my lab under one condition; I update him regularly on my side research.”

  “How did this second phase of your research at L’Oreal go?”

  “Well, there were three major breakthroughs. First, I was able to produce telomerase, the enzyme that preserves telomeres, therefore guaranteeing perfect cell duplication. This happened in the fall of 1970. Second, I was able to design a drug that transferred telomerase into human skin cells to make them effectively immortal. This was the first prototype of Telomerax.

  And third, we started experimenting on human patients. Xavier knew a Swiss doctor named Hans Klettendorf, who was the owner of a fancy beauty clinic called “Le Jardin de Venus” in the Perroy village, off the coast of the lake of Geneva.

  There was an agreement that allowed L’Oreal to use the rich and famous customers of this beauty farm to test its new products. Obviously with their consent, and under the full control of an experienced staff. To my surprise, I saw that these special kind of guinea pigs were very eager to undergo risky experiments in exchange for the privilege of accessing the latest rennovations in aesthetic care.

  No one except Xavier and I knew that the skin cream was also the first Telomerax prototype and since the clinic customers knew they were using experimental cosmetics, they did not mind if from time to time an expert would come for a few checkups.

  The results were absolutely amazing. The skin of the patients treated with the prototype clearly showed a sudden stop in the aging process, to the extent that they were considering reducing the frequency of their other cosmetic treatments. Of course, all the rest of their body was still subject to aging but the results were simply shocking. So I pushed myself to work harder, and Xavier became more and more intrusive on my research, making me feel as if I was suffocating under pressure.

  Then I discovered the reason behind his intrusion. L’Oreal was planning to buy Synthelabo, a French pharmaceutical company that was renowned for its research in dermatology. That was why Xavier needed to know all the points he could bank on before heading into the acquisition. In addition, my research would have had to be combined into the one of Synthelabo. The message was very clear, freedom to complete my research in private was diminishing.”

  “How did you manage to defend your independence?”

  “L’Oreal acquired Synthelabo in 1973, a
nd then all of the usual company integration problems surfaced; redundant research projects, competition among different teams and the like. On my end, more and more time wasted on company turf wars. And then came the death of my father, which reopened my eyes to focus on my actual goal. If you believe in fate, that was a sign. So I made up my mind, and I decided it was high time to switch up my career again.

  I went to Xavier’s office and asked to leave the company. It was time for me to setup my own shop and, with the respectable amount of money I had earned so far, I would ask Hans Klettendorf to become his partner at “Le Jardin de Venus.”

  The explanation I gave Hans for the abrupt change, was that it was time for me to fulfill my entrepreneurial dream. I emphasized the fact that I was bringing a good amount of capital, knowledge, and experience to increase the clinic business and set up its own exclusive cosmetic lab.

  The key advantage of teaming up with me, for Hans, was that he would secure a solid future for his business, at seventy-two years old. This implied that his two sons - neither showing interest to follow in their father’s footsteps - could continue to benefit from the profits, while devoting themselves to their favorite hobbies. Only Xavier knew the real reason for my leave, and kept this as the focus during our last meeting.

  “Louis,” he said, “I admire your commitment but have you ever considered all the consequences? I mean, it could go wrong.”

  “You mean, what if I do not end up with solid results? Well, you know, people will move on from where I left…”

  “No, Louis, what if you succeed and you find your potion of eternal life? You are either ignoring the implications, or simply pretending there are none.

  Do you think you can sort it out by publishing an article in Nature magazine, like your heroes Francis and Crick did, and then wait for the Nobel Prize and that’s it?”

  “Of course not, Xavier. It will be incomparably larger than Penicillin; a revolution.”

  “Far more than a revolution. Think about it. Everything is based on this very simple and undeniable truth, that we are mortals. Life is just a brief journey, then you go to Hell, or Heaven, or nowhere, but you make room for somebody else. Everything is programmed around this. And if you succeed, the whole system collapses. There is maybe far more to lose than to gain, from a human standpoint, of course.”

  “Well, I agree it won’t be easy to adapt to, but this is the ultimate goal for me and I believe for all of us. Plus, we are almost there. I feel it. The criminal act, or rather the inhumane one, would be to give up for fear, Xavier. And honestly, I am quite surprised that this objection comes from an enlightened and rational person like yourself.”

  “I know I can’t stop you, Louis. This is your passion. But please think. And watch out. It could become very dangerous for you, and those around you. And do not hesitate to come back if you need help.”

  We never got in touch again. The next time I would see Xavier, would be at his funeral in 1985. He died in a car crash, and by that time I had already been testing the first versions of Telomerax on myself for a few years.

  I find it quite ironic how I arrived at the ceremony as the first immortal being on Earth, being proven against by the unpreventable death of my friend. Yet Xavier had made a good point. From that moment on, I was no longer under the protection of a company. I was at high seas, with a powerful treasure that had to be defended from a multitude of threats, by any means necessary. The first mission was to keep it a secret.